| abstract |
The present invention relates to derivates of an insulinotropic peptide Exendin-4 andnpharmaceutically acceptable salts produced thereof, which are useful for the treatment of type IIndiabetes. Exendin-4 has the chemical structure as shown below:n n In which: n X represents Arg, Leu or Ile, Y represents His, Arg or Lys and Z represents Arg-OH, -OH,n- NH2 or Lys-OH. n The derivates of this invention may be prepared by synthetic chemical means, and moreneasily, by the recombinant techniques, which makes it possible to commercial production. |