| abstract |
This invention relates to benzimidazolone derivatives,nrepresented by compounds of a general formula [I]n n [in which R 1 and R 2 stand for, e.g., hydrogen atoms; R 3a , R 3b , R 4 ,nR 5 stand for, e.g., hydrogen atoms and alkyl groups; R 6 stands for e.g.,naryl or heteroaryl groups; A ring stands for 5- to 8-membered aliphaticnheterocyclic ring containing one nitrogen atom; and Z stands forncarbonyl group or sulfonyl group]. n The benzimidazolone derivatives of the invention exhibitnantagonism to muscarinic acetylcholine receptors, and are useful asntreating agent and/or prophylactic of Parkinson's disease;ndrug-induced parkinsonism, dystonia, akinesia, pancreatitis,nbilestone/cholecystitis, biliary dyskinesia, achalasia, pain, itch,ncholinergic urticaria, irritable bowel syndrome, vomiting, nausea,ndizziness, Meniere's disease, motion sickness and urinary disturbance. |