| abstract |
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially unsaturated heterocyclic ring, or an N-linked 6-membered di-hydro-heteroaryl ring; and Q is, for example, Q1 or Q2: wherein R<2 >and R<3 >are independently hydrogen or fluoro; T is selected, for example, from a group of the formula (TA1) or (TA2): wherein, for example, X1m is O= and X2m is R2s-(E)ms-N-; wherein E is an electron withdrawing group, for example, -SO2- or -CO-; and, for example, R2s is hydrogen or (1-6C)alkyl; are useful as pharmaceutical agents; and processes for their manufacture and pharmaceutical compositions containing them are described. |