http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1381681-B1

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filingDate 2002-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98a60b0b67fd002d1daf831d37f9a984
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publicationDate 2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1381681-B1
titleOfInvention The nk1 fragment of hepatocyte growth factor/scatter factor (hgf/sf) and variants thereof, and their use
abstract The present invention relates to variants of the NK1 fragment of the polypeptide growth factor HGF/SF which act as agonists of the MET receptor and their use. The agonists comprise at least one substitution at positions equivalent to 132, 134, 170 and 181 of full length HGF/SF and these substitutions provide a variant which shows scatter factor activity and induces DNA synthesis. In vivo the variants provide protection from liver damage in a model of acute liver failure.
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