| abstract |
The present invention intends to provide a screening ofnagonist/antagonist and the like. Specifically, the invention provides anmethod of screening a compound or its salt that alters the binding propertynbetween a novel G protein-coupled receptor protein or its salt, and ansubstance relating to cholesterol metabolism, which comprises using thenreceptor protein or its salt, which contains the same or substantially thensame amino acid sequence as the amino acid sequence represented bynSEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 14 or SEQ IDnNO: 16, and the substance relating to cholesterol metabolism. |