abstract |
The invention provides a cyclic single-chain trispecific antibody against humanntumor. It comprises three parts. The first part is an anti-tumor Fab antibody, annanti-tumor single-domain antibody or an scFv. The second part is a reshaped Fabnantibody against human CD3, a reshaped single-domain antibody against human CD3nor a reshaped scFv against human CD3. The third part is a reshaped Fab antibodynagainst human CD28, a reshaped single-domain antibody against human CD28 or anreshaped scFv against human CD28. The present invention also offers the DNAnsequence coding for this trispecific antibody, expression vectors containing this DNAnsequence and host cells (E. coli) containing the vectors. |