| abstract |
The present invention is to prepare efficientlyn2'-amino-5'-hydroxypropiophenone corresponding to the AB-ringnpart of camptothecin (CPT) skeleton and a tricyclic ketonencorresponding to the CDE-ring part in order to providenefficiently CPT by the total synthesis, which is a startingnmaterial for irinotecan hydrochloride and various kinds ofncamptothecin derivatives, and to provide stably CPT and itsnderivatives. |