| abstract |
It will be a method of testing the hormonal effect, especially the androgenic ornantiandrogenic effect, described by substances in which a) cells using two vectorsnare transfected, the vector being a DNA for a nuclear receptor protein or anFragment of which is encoded, and the other vector contains DNA, necessary for the co-modulatornHSRNAAM or a fragment thereof, are exposed to the substance and b) thenTranscriptional activity that the nuclear receptor or its fragment in the presence ofnTriggers co-modulator or its fragment, and / or the influence of the substance on thenInteraction between the receptor or its fragment and the co-modulator or itsnFragment measured by protein-protein interaction or protein-protein-DNA interactionnbecomes. Furthermore, a method for determining interference in the co-modulation mechanismnbetween androgen receptors and HSRNAAM. |