| abstract |
An aryl-substituted alicyclic compound represented by the general formula (1): (1) wherein U represents 1,4,5,6-tetrahydropyrimidine-2-yl group or the like, A represents a phenylene group or the like, B represents pyperidine-1,4-diyl group or the like, Z represents -CONH- or the like, R3 represents hydrogen or the like, R5 represents hydrogen, an aryl group or the like, R6represents a monosubstituted amino group, such as a benzyloxycarbonyl amino group, or the like, and R7 represents hydrogen or the like, a prodrug thereof, a physiologically acceptable salt thereof, an N-oxide derivative thereof, a hydrate thereof, or a solvate thereof; a method for the preparation thereof; and a medical composition comprising the compound or the like. The compound exhibits high selectivity for αvβ3 integrin and has strong inhibiting action, and thus is useful as a preventive and/or therapeutic drug for a disease with which avß3 integrin concerns. |