abstract |
An aryl-substituted alicyclic compound of the formula (I):n nwherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc.,nB is piperidine-1,4-diyl, etc., Z is -CONH-, etc., R 3 is hydrogen, etc., R 5 nis hydrogen, aryl, etc., R 6 is a mono-substituted amino (e,g., benzyloxycarbonylamino),nR 7 is hydrogen, etc., and a process for preparationnthereof, and a pharmaceutical composition containing the same. Thencompound of the present invention has a high selectivity for αvβ3nintegrin, and exhibits a potent inhibitory activity thereto, and hence, itnis useful as a preventive or/and a therapeutic agent for a disease innwhich αvβ3 integrin is involved. |