http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1370871-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_389755f3704fd12032828183d71f51fd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-705 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2002-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c9d954b9d6b2825f7b84cfef966578e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa7d36167ca453fbffecc1bac4ef5186 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2fbad23a4b7d0a614ee82a93b1b6c85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57afe7f4c40316c59f4b8e7c913dc57c |
| publicationDate | 2003-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1370871-A2 |
| titleOfInvention | Screening system based on expression of abcg2 half transporter protein |
| abstract | The overexpression of an ABC half-transporter, ABCG2 (MXR/BCRP) transporter causes multidrug resistance in tumors. The present invention is based on the in vitro expression of the ABCG2 protein in insect cells as an expression system free of other, closely related, functional ABC transporters. In particular, the invention is related to a method for testing drugs for their effect on ABCG2 protein, method for the expression of active ABCG2, isolated ABCG2 homooligomers, preferably homodimers and uses thereof for testing drugs. The invention is further related to cell membrane preparations and cells, preferably insect cells comprising active ABCG2 and reagent kits for testing drugs for their effect on an ABCG2 half transporter protein. The invention is also related to a method for identifying ABCG2 activity in a biological sample, utilizing its substrate/inhibitor specificity. |
| priorityDate | 2001-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 276.