| abstract |
Methods of increasing the growth rate of a human patientnhaving partial growth hormone insensitivity syndrome, butnnot Laron syndrome, are described. One such methodncomprises administering an effect dose of growth hormone,npreferably growth hormone with a native human sequence,nwith or without an N-terminal methionine, to the patient.nThe patient is characterized as having a height of lessnthan about -2 standard deviations below normal for agenand sex, a serum level of high-affinity growth hormonenbinding protein that is at least 2 standard deviationsnbelow normal levels, a serum level of IGF-I that is belownnormal mean levels, and a serum level of growth hormonenthat is at least normal. In another such method, thensame patient population is treated with an effectivenamount of IGF-I, given alone or in combination with annamount of growth hormone that is effective in combinationnwith the IGF-I. |