| abstract |
A metered dose inhaler comprises a canister a crimped cap covering the mouth ofnthe canister and a drug metering valve situated in the cap, for dispensing anninhalation drug formulation comprising salmeterol, or a physiologically acceptablensalt thereof, and a fluorocarbon propellant, optionally in combination with one ornmore other pharmacologically active agents or one or more excipients, said meteredndose inhaler having part or all of its internal surfaces coated with one or morenfluorocarbon polymers, optionally in combination with one or more non-fluorocarbonnpolymers and wherein the canister is a strengthened canister having a reducedntendency to malform under high temperatures, comprising side walls and base ofnincreased thickness. |