| abstract |
The present invention relates to a method for detection of somatic mutations in samples. The methodnis based on detection of somatic mutations by means of mass spectrometry, whereby a comparisonnof complex signal patterns comprising aberrant signals compared to wild type and/or integrals overnparticular peaks within the spectra is used for assessing the presence or absence of mutations innnucleotide sequences. According to the method disclosed herein a ratio of the signal integrals of anreference peak and a peak to be analysed are built. The peaks employed for the comparison arenchosen to allow for a reproducible correlation of the ratios of the integrals to the particular somaticnmutation phenotype. |