| abstract |
A novel compound having an excellent antagonistic effect on a corticotropin-releasing-factor receptor. It is a compound represented by the following formula or a salt thereof. (I) In the formula, R1 represents hydrogen, C¿1-6? alkyl, C1-6 alkoxy, etc.; R?2¿ represents halogeno, cyano, nitro, C¿1-10? alkyl, C2-10 alkenyl, C2-10 alkynyl, etc.; R?3¿ represents an optionally substituted C¿6-14? aromatic hydrocarbon group or an optionally substituted, 5- to 14-membered aromatic heterocyclic group; and X, Y, and Z each independently represents nitrogen or CR?4¿ (wherein R4 represents hydrogen, halogeno, cyano, nitro, optionally halogenated C¿1-6? alkyl, etc.), provided that at least two of X, Y, and Z represent CR?4¿. |