http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1363945-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de6ab3a0fb80329b3d632fecdeb0405d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-595 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-595 |
| filingDate | 2002-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8663924967ce19ad64ac5794656d18f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db2489cf47a2e1fa72867a00b4cccd82 |
| publicationDate | 2003-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1363945-A2 |
| titleOfInvention | Modified derivatives of cck-8 |
| abstract | The invention provides a peptide based on biologically active CCK-8 having improved characteristics for the treatment of obesity and/or type 2 diabetes wherein the primary structure of CCK-8 is: Asp<SUP>1</SUP>Tyr<SUP>2</SUP>(SO<SUB>3</SUB>H)-Met<SUP>3</SUP>Gly<SUP>4</SUP>Trp<SUP>5</SUP>Met<SUP>6</SUP>Asp<SUP>7</SUP>Phe<SUP>8</SUP>amide (SEQ ID NO:1) and wherein the peptide has at least one amino add substitution and/or modification and is not Asp<SUP>1</SUP>-glucitol CCK-8. The invention also provides the use of the peptide in the preparation of a medicament to inhibit food intake, induce satiety, stimulate insulin secretion, moderate blood glucose excursions, enhance glucose disposal and/or exhibit enhanced stability in plasma compared to native CCK-8 and/or for treatment of obesity and/or type 2 diabetes. |
| priorityDate | 2001-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 211.