| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2003-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f71762cdac2868e0aa352acf3ef9d545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cb365bd680992f0a4850fdbbba48bdd |
| publicationDate |
2003-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1362914-A2 |
| titleOfInvention |
Histone deacetylase inhibitor and use thereof |
| abstract |
To provide a novel apoptosis inducer, and a methodnof screening an apoptosis inducer. For example, annapoptosis inducer comprising inhibiting HDAC6 such as annantisense oligonucleotide to the gene of histonendeacetylase 6 (HDAC6), and anti-cancer agent comprisingnthis apoptosis inducer, and the present invention alsonprovides a method of screening an apoptosis inducer thatninhibits HDAC6, and more specifically a method ofnscreening an apoptosis inducer said method comprising thensteps of (1) determining whether or not a test substanceninhibits histone deacetylase 6 (HDAC6) by usingndeacetylation of an acetylated substance that can be ansubstrate for histone deacetylase 6 (HDAC6) or decreasenin the expression of histone deacetylase 6 (HDAC6) as annindex; and (2) confirming, when inhibition is present,nwhether it induces apoptosis of the cell in vitro and/ornin vivo. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010045224-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010045224-A2 |
| priorityDate |
2002-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |