http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1362510-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ec80013bc1fa789ce11132853e8ffe3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2003-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c6a9cc2eeed5f5dbb281a1d372b8d26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45bebc98b164bd021a120f2a2cb932b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bab6382e8f111ee0a88fe3539c95bb29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26386c490866c94dfda92068a5cd8e6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50d1fc09c906f72e1e7a777f0a0bbe9e |
| publicationDate | 2006-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1362510-B1 |
| titleOfInvention | A mouse model for hepatocellular carcinoma by targeted integration of hepatitis B virus genes |
| abstract | The invention provides a mouse model of hepatocellular carcinoma and a method for establishing an animal model comprising: a) inserting an exogenous gene of interest into a suitable vector carrying sequences homologous to a target site, to construct a recombinant targeting vector; b) transfecting ES cells of a studied animal using said targeting vector from step a), and screening targeted ES cells which have integrated the exogenous gene into a specific site; c) injecting targeted ES cells obtained from step b) into said animal's blastulas and culturing the blastulas in vitro, so that embryos containing targeted ES cells are generated; and d) implanting embryos generated from step c) into said animal's uterus, thereby progeny expressing the exogenous gene stably is developed. <??>The invention further relates to the use of said transgenic mouse in research of hepatocellular carcinoma pathogenesis, its early stage diagnosis and therapy, and screening of anticancer drugs. <IMAGE>The invention provides a mouse model of hepatocellular carcinoma and a method for establishing an animal model comprising: a) inserting an exogenous gene of interest into a suitable vector carrying sequences homologous to a target site, to construct a recombinant targeting vector; b) transfecting ES cells of a studied animal using said targeting vector from step a), and screening targeted ES cells which have integrated the exogenous gene into a specific site; c) injecting targeted ES cells obtained from step b) into said animal's blastulas and culturing the blastulas in vitro, so that embryos containing targeted ES cells are generated; and d) implanting embryos generated from step c) into said animal's uterus, thereby progeny expressing the exogenous gene stably is developed. <??>The invention further relates to the use of said transgenic mouse in research of hepatocellular carcinoma pathogenesis, its early stage diagnosis and therapy, and screening of anticancer drugs. <IMAGE> |
| priorityDate | 2002-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.