abstract |
The present invention relates to a multi-layered,nphysiologically tolerated oral dosage form fornpharmaceutically active compounds. The dosage formncomprises a central core, a middle layer, and an outernshell, at least one of which includes at least onenpharmaceutically active substance. By varying thendiameter of the core, a different middle layer volume isnobtained within a fixed outer shell dimension. Thisngives the ability to obtain different dosage strengthsnfor one composition without the need of reformulationnwork. The oral dosage form is produced in a single-step,ncontinuous process by coating the core with thenmiddle layer and the outer shell. |