abstract |
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is -CH 2 -OH, -CH 2 NH 2 , -NHSO 2 CH 3 , and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarbox-amides, hydroxyamidines and formamides are preferred. |