| abstract |
Drugs useful as preventives and remedies for urinary frequency, urinary incontinence, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, arthritis deformans, pain, cough, irritable bowel syndrome, vomiting, depression, anxiety, manic-depression or schizophrenia which comprise a combination of an NK-1 receptor antagonist and an NK-2 receptor antagonist and/or a cholinolytic. More specifically, drugs comprising a combination of a compound represented by the following formula (I) [wherein the ring M represents a heterocycle having, as the partial structure -X-Y< thereof, -N=C<, -CO-N< or -CS-N<; R?a and Rb¿ are bonded to each other to form the ring A, or R?a and Rb¿ may be the same or different and each represents hydrogen or a substituent in the ring M; the rings A and B are each an optionally substituted homocycle or heterocycle and at least one of them is an optionally substituted heterocycle; the ring C is an optionally substituted homocycle or heterocycle; the ring Z is an optionally substituted nitrogen-containing heterocycle; and n is an integer of 1 to 6], its salt or a prodrug thereof with an NK-2 receptor antagonist and/or a cholinolytic: (I) |