| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2001-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b22912639f430d00b2cbb055f99ca9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5259244bc07e726c05154204a91e0f70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dd864f8550c8f1dfceee53673f9c4f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f74585a2ca7edafc405ab2d14910aef6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71e24eda8e28315d772c58a9326bb6ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ce0d769b4c2b76da9f035e447e20471 |
| publicationDate |
2004-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1351709-B8 |
| titleOfInvention |
Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| abstract |
The present invention is directed to the site-specific PEGylation of immunoconjugates. In particular, the present invention provides immunoconjugates wherein a connector molecule attaching a targeting molecule to an effector molecule is conjugated to one or more polyethylene glycol molecules. The present invention further provides methods for increasing the antitumor activity of an immunotoxin, comprising attaching in a site-specific manner one or more polyethylene glycol molecules to a linker connecting a toxic moiety to a targeting moiety of an immunotoxin. |
| priorityDate |
2000-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |