| abstract |
This invention provides caspase inhibitors having the formula (I): wherein R1 is CO¿2?H, CH2CO2H, or esters, amides or isosteres thereof; R?2 and R3¿ are each independently selected from hydrogen or an optionally substituted C¿1?-C6 aliphatic group; and R?4 and R5¿ are each independently selected from hydrogen, an optionally substituted C1-C6 aliphatic group, or R?4 and R5¿ taken together with the ring to which they are attached form an optionally substituted bicyclic ring. The caspase inhibitors are useful for treating a number of diseases such as cancer, acute inflammatory and autoimmune disorders, ischemic diseases and certain neurodegenerative disorders. |