| abstract |
4-aryl pyrimidine compounds of general formula and salts thereof:wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C¿1-6? alkoxy, etc.; R?2¿ is hydrogen, halogen, etc.; R3 is hydrogen, hydroxy, halogen, amino, etc.; R4 is hydroxy, amino, carboxy, etc. or R?3 and R4¿ together form a ring; R5 is hydrogen, carbamoyl, cyano, carboxy, C¿1-16? alkoxycarbonyl, etc. and R?6¿ is amino or C¿1-16? alkanoylamino or R?5 and R6¿ together form a ring. The compounds (I) or the salts thereof have an excellent anti-inflammatory activity and act as inhibitors of IKK-β and thus inhibit nuclear factor kappa B(NF-¿K?B). |