| abstract |
Cyanopyrrolidine derivatives represented by the general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein R1 is halogeno, hydroxyl, or the like, and R2 is hydrogen, halogeno, or the like, or alternatively R?1 and R2¿ are united to form oxo, hydroxyimino, or the like; R?3 and R4¿ are each hydrogen, halogeno, or the like, or alternatively R?3 and R4¿ are united to form oxo, hydroxyimino, or the like; X is oxygen or sulfur; Y is CR5R6- (wherein R?5 and R6¿ are each independently hydrogen, halogeno, or the like) or CR?7R8-CR9R10¿- (wherein R?7, R8, R9, and R10¿ are each independently hydrogen, halogeno, or the like, or alternatively R?7 and R9¿ together with the carbon atoms adjacent thereto form C¿3-8? cycloalkyl or the like); and Z is hydrogen, C1-10 alkyl, or the like, or alternatively Y and Z together with the nitrogen atom adjacent thereto form cyclic C2-10 amino or the like. |