| abstract |
The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamidenderivative represented by thengeneral formula:n nwherein R 1 is a hydrogen atom or an optionally substituted lowernalkyl group; nR 2 is a di(lower alkyl)amino group, a lower alkyl group, ancycloalkyl group, an optionally substituted aryl group, annoptionally substituted heterocycloalkyl group, or an optionallynsubstituted aromatic heterocyclic group; nT is an oxygen atom, a sulfur atom, a sulfonyl group etc.; nQ is a hydrogen atom or an optionally substituted lower alkylngroup; and nZ is a hydrogen atom, a hydroxy group etc., nor a pharmaceutically acceptable salt thereof, which exert anpotent and selective activated blood coagulation factor Xninhibitory activity and is useful as an agent for the preventionnor treatment of a disease associated with an activated bloodncoagulation factor X, a pharmaceutical composition comprisingnthe same, a pharmaceutical use thereof and an intermediatenthereof. |