abstract |
The present invention is related to syntheticnribozymes, i.e. ribozymes including a hairpin portion,nbinding sites for binding to a human papilloma virus (HPV)nafter viral base 419 or 434, respectively, and cleavagensites for cleaving HPV virus are disclosed. The inventionnalso includes a diagnostic assay for determining thenpresence of HPV-16 in tissues based on PCR amplification. |