| abstract |
The present invention provides oral preparations withngood disintegration containing a slightly water-solublenactive ingredient, which comprise a mixture of a solidnformed product (e.g. a granule) and a second disintegrantnwherein said solid formed product comprises a slightlynwater-soluble active ingredient, a first disintegrant and anwater-soluble excipient which is formed by using a water-solublenpolymer binder; or comprises a solid formed productnprepared from a slightly water-soluble active ingredient, andisintegrant and a sugar alcohol by using a water-solublenpolymer binder. When orally administered, these oralnpreparations exhibit excellent dissolution characteristicsnof the active ingredient in the digestive tract, andnfurther, these preparations can show equivalent dissolutionnprofile even at different amounts of the active ingredient,nand thus enable the selection of the most suitablenmedicament for each patient, which makes these preparationsnhighly useful in the clinical field. |