| abstract |
Specific phenylalanine derivatives or pharmaceutically acceptablensalts thereof have an antagonistic effect on the α4 integrins and,ntherefore, are usable as therapeutic agents or preventive agents forndiseases in which α4 integrin-depending adhesion process participatesnin the pathology, such as inflammatory diseases, rheumatoid arthritis,ninflammatory bowel diseases, systemic lupus erythematosus, multiplensclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes,ncardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation,ntumor metastasis and transplantation rejection. |