| abstract |
The first aspect of the present invention relates to transition metal complexes having the formula (I) or (II) wherein M is a radioactive metal having a valence of +2, +3, +4, or +5; m+ designates the charge of the metal complex, each R is independently C¿1?-C8 linear or branched alkyl, a fifth ligand, and mixtures thereof; B is a bridging unit which comprises at least 2 carbon atoms; L is a pharmaceutically acceptable ligand; X is a pharmaceutically compatible anion in sufficient amount to provide electronic neutrality. The complexes of the present invention are suitable for use in diagnostic, therapeutic or radiotherapeutic or chemotherapeutic compositions for visualization, therapy, chemotherapy or radiotherapy of tissues or organs. |