http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1317175-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a988d289fccdd1c4ffd4eb946b7fa25 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0247 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 |
| filingDate | 2001-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e81bc5c900eced0a74a37f75fdb6226 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ab71f9b5364f9c01c6b340a0d96ffc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dac480aba8035404821714c378c38752 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9778474d0fa84b38a2ef7c0860c1adc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_655885b9c147008873d855566ef1315d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4477a1e37aed5b0e2ace27b018b132d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e5feb8ea686dddd2227b7afe152075e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_438a5797eb3c0153a10453ae82ccbdf1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31d1edd2a0e18ea42eca1a2e865b7cdb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84b27ce55e2beb9613e786e83726709f |
| publicationDate | 2012-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1317175-B1 |
| titleOfInvention | Apparatus for maintaining and/or restoring viability of organs |
| abstract | An organ perfusion apparatus and method monitor, sustain and/or restore vability of organs and preserver organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygeneted cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubuing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization preventing and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of th emedical fluid perfusate. The perfusion process can be automatically controlled using a control program. |
| priorityDate | 2000-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 354.