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filingDate 2001-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_631835b388746e66fbb92e96c09c150f
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publicationDate 2003-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1308462-A1
titleOfInvention Hepatitis b virus (hbv) antigenic polypeptide-heat shock protein complex and use thereof
abstract The present invention provides a kind of HBV-antigen bound to heat shocknproteins(hsps) which comprises core antigen, surface antigen and polymerasenantigen. The present invention also provides a complex of HBV antigen bound tonheat shock protein gp96 and hsp78, as well as a method for preparing the complex.nThe complex includes a complex of gp96 and hsp78 non-covalently bound tonantigenic polypeptide, as well as a fusion protein of both which results from covalentnbinding. Such complex can be used to prepare therapeutic vaccine for treatingnhepatitis B and primary hepatocellular carcinoma.
priorityDate 2000-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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