http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1307423-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ee82f835b23386f3e9a32a91a272b3a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-313 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-313 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
| filingDate | 2001-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a3aaa5facfa7570bb77e1f01b642e66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9daf25ff8989b1bcf4f16ea097d7f27d |
| publicationDate | 2008-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1307423-B1 |
| titleOfInvention | Processes for the production of fexofenadine |
| abstract | An improved process for the manufacture of fexofenadine is described in which a compound of formula (F): wherein R<SUB>2 </SUB>represents COOH, COO-C<SUB>1-6 </SUB>alkyl or CN; and R<SUB>3 </SUB>represents hydrogen, mesylate, triflate, tosylate or carboxy-C<SUB>1-6</SUB>-alkyl, or a salt thereof is prepared by: (I) reacting a compound of formula (B): wherein R1 represents hydrogen or carboxy-C<SUB>1-6</SUB>-alkyl; and R<SUB>2 </SUB>is a hereinbefore defined, with a copper and/or silver compound in the presence of palladium or a compound thereof to yield a compound of formula (C): wherein R<SUB>1</SUB>, and R<SUB>2 </SUB>are as hereinbefore defined; (II) converting said compound of formula (C) into a compound of formula (E): wherein R<SUB>2 </SUB>and R<SUB>3 </SUB>are as hereinbefore defined and R<SUB>4 </SUB>represents a halogen atom, and (III) reacting said compound of formula (E) with azacyclonol. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107782804-A |
| priorityDate | 2000-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 134.