| abstract |
Process for the preparation of substituted thiazolines of the formula (1) in the Ar are a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical, which is optionally substituted by one or more substituents from the group halogen, OH, benzyloxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy , COOR 1 can be substituted with R 1 equal to H or C 1 -C 4 alkyl, by coupling (S) -α-methylcysteine hydrochloride of the formula (II) with a nitrile of the formula (III) Ar-CN in the Ar is as defined above, or a corresponding C 1 -C 4 alkylimidate, in which (S) -α-methylcysteine hydrochloride of the formula (II) in a suitable solvent with a nitrile of the formula (III) or a corresponding C 1 -C 4 alkyl imidate is reacted in the presence of a tertiary base at a pH of 6.5 to 10 at 50 ° C. to the reflux temperature to give the corresponding thiazoline of the formula (I), and process for the preparation of (S) - α-Methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I). |