| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c273ba937f4a0abe126d0e5d800966a8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate |
2001-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351228e09ab930dcd074cca4eb8bfe62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ced3be5cde14ac8ffdec943f980925bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ade93f402382a3d1063ae57500464aa4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_533f03394574dc691da290ee2df60c78 |
| publicationDate |
2003-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1301184-A2 |
| titleOfInvention |
Valproic acid and derivatives thereof as histone deacetylase inhibitors |
| abstract |
The present invention relates to the use of valproic acid and derivatives thereof as an inhibitor of histone deacetylases. The invention also concerns the use of those compounds for the manufacture of a medicament for the treatment of diseases associated with histone hypoacetylation or in which a therapeutic effect can be achieved by induction of increased histone acetylation, such as tumors or leukemias, myelodysplasic syndrome or thyroid resistance syndrome. Also provided are methods for screening compounds having histone deacetylase activity using valproic acid/derivative thereof, and methods for identifying genes induced by valproic acid/derivatives thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7994357-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2236503-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2277387-A1 |
| priorityDate |
2000-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |