http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1298145-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfd617dc43a4c986d2dd81e4cb39d9dd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2001-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53897f0cfc01e9388d8ac20a28cfcb39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05e22a779da4e7e1bc9b49f45304f917 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faf825689d130d1d7a709bf3a115e64e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8e77864b398babd1372047e1893f35d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_222bb8e633a64feb11a9668a331581c5 |
| publicationDate | 2003-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1298145-A1 |
| titleOfInvention | Dds compound and process for the preparation thereof |
| abstract | A DDS compound in which amino group at 1-position of (1S,9S)-1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo[de]pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-10,13(9H,15H)-dionenas a drug compound is bound to ancarboxyl group of a carboxymethyldextran polyalcohol with a spacer containing onenamino acid or two to eight amino acids linked by peptide bond(s); characterized in thatnan introduced amount of residue of the drug compound is in a range of from 3.2% ton8.4% by weight; a weight-average molecular weight of the carboxymethyldextrannpolyalcohol is in a range of from 240,000 to 480,000; and degree of carboxymethylationnis in a range of from 0.14 to 0.47; and a method for preparing said DDS compound,nwhich comprises the steps of, for example, adding an aqueous solution containingnsodium periodate to an aqueous solution containing dextran at a temperature of 4°C ±n2°C to oxidize the dextran, and then adding the resulting reaction mixture to annaqueous solution containing sodium borohydride at a temperature not higher than 15°Cnto obtain a dextran polyalcohol. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10258579-B2 |
| priorityDate | 2000-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.