| abstract |
This invention provides amino acid N-carboxyanhydrides,neach of which has an N-acylnsubstituent on its nitrogen atom, is represented by thenfollowing formula (1):n nreadily reacts with nucleophilic reagents such as freenamino acids, alcohols, anions or the like, and arenintermediates useful for the high-yield production ofnamino acid derivatives, optically active compounds,npeptides, polypeptides and the like useful in many fieldsnlead by the fields of pharmaceuticals and agrochemicals,nand also provides a process for the production of thenamino acid N-carboxyanhydrides. Further, the presentninvention also provides a process for the production ofndiamides, which uses the compounds of the formula (1) andnamine derivatives represented by the following formulan(7):n n These diamides can also be suitably used for thenproduction of amino acid derivatives, optically activencompounds, peptides, polypeptides and the like. |