| abstract |
The present invention provides a preventive orntherapeutic agent for hyperlipidemia, comprising as annactive ingredient a heterocyclic compound of the formulan[1] or a pharmaceutically acceptable salt thereof:n R 1 ―Het―D―E nwherein:n R 1 is optionally substituted aryl or aromaticnheterocyclic group, Het is a divalent aromatic heterocyclicngroup, D is alkylene, alkenylene, alkynylene, or the like,nand E is carboxy, or the like, and novel compounds amongnthe heterocyclic compounds of the formula [1] above, whichnhas blood triglyceride lowering effect, LDL-C loweringneffect, and blood glucose lowering effect and blood insulinnlowering effect, or HDL-C increasing effect or atherogenicnindex lowering effect all together, and hence is useful innthe prevention or treatment of hyperlipidemia,narteriosclerosis, diabetes mellitus, hypertension, obesity,nand the like. |