| abstract |
The invention concerns a vaccine against foot-and-mouth disease, using as antigen an efficient amount of empty capsids of the foot-and-mouth virus, said empty capsids being obtained by expressing, in eukaryotic cells, cDNA of the P1 region of the foot-and-mouth virus genome coding for the capsid and cDNA of the region of the foot-and-mouth virus genome coding for protease 3C, the vaccine further comprising a carrier or excipient pharmaceutically acceptable in veterinary medicine. The invention also concerns the insertion of a mutation in the sequence VP2 (introducing a cysteine), thereby stabilising the empty capsids and the resulting viruses. |