| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1234 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-40 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M36-12 |
| filingDate |
2001-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bff540717810663d13a761af203285b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f28352722de642a39f848bc18c95d30a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1674120d950b7852dcf2fcc0003af78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b55fa39ea720561b946abad593f85378 |
| publicationDate |
2003-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1289570-A1 |
| titleOfInvention |
Liposomal encapsulation of chelated actinium-225 and uses thereof |
| abstract |
Actinium-225 and other alpha particle-emitting radionuclides hold great promise as potential therapeutic agents for cancer treatment. However, use of these radionuclides is limited by systemic toxicity resulting from release of administered radionuclides and radioactive decay products thereof. If the radionuclides are confined to the target cells, efficacy is increased and toxicity is decreased. However, covalent linking of the radionuclides to targeting molecules does not prevent toxicity resulting from the systemic release of alpha-particle emitting daughter radionuclides. The present invention provides targeted delivery of alpha particle-emitting radionuclides and their alpha-emitting progeny using liposomal encapsulating to prevent the loss of progeny radionuclides from the targeting vehicle and, therefore, the tumor site. |
| priorityDate |
2000-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |