| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a148f8fb7bede6880babc1db1523482e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate |
2002-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2003-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1288211-A1 |
| titleOfInvention |
Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide |
| abstract |
A process for the preparation of 1-(4'-fluorophenyl)-1-(3-dimethylamino-propyl)-5-phthalanecarbonitrilenof formula (I), or a pharmaceutically acceptable salt thereof,n ncomprising performing two successive Grignard reactions on 5-bromophthalide,nwherein the 5-bromophthalide is reacted with the first Grignard reagent in thenpresence of a Lewis acid, so reducing by-product formation and improving yields. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2418916-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005012278-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005012278-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7511161-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004011450-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2418916-A |
| priorityDate |
2001-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |