http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1287847-A1

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filingDate 2002-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7b77613f51b9c88beef809ce86148dc
publicationDate 2003-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1287847-A1
titleOfInvention Improved micro-needles and methods of manufacture and use thereof
abstract A micro-needle (80) is provided which is particularly useful for the minimally invasivensampling of a biological fluid and/or the minimally invasive delivery of a drug or othernformulation across the skin. The micro-needle (80) has a structure having a base (70) at a proximalnend and a vertex (60) at a distal end (58), and an open lumen (55) extending there through and throughnwhich fluid may be transferred. The structure defines a structural axis (65) that intersects thenlumenal axis (56) defined by the open lumen (55). The point of intersection (90) between these axes is at anpoint below the vertex (60) of the micro-needle (80) to provide a sharp apex (60) at the distal end (58) of thenmicro-needle (80) and defines the general configuration of the distal end (58) of the micro-needle (80),nwhich may be selected or customized depending on the intended use of the microneedle (80).nThe micro-needle (80) may be integral with a measurement device for measuring thenconcentration of a constituent within sampled biological fluid and/or with a fluid reservoirnfor containing a fluid to be delivered, and may also be used in conjunction with a remotencontrol means. Methods of making and using the micro-needle (80) of the present invention asnwell as kits comprising one or more of the micro-needles (80) are also provided.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1321706-C
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8088321-B2
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