abstract |
The present invention describes methods for using methioninase as an antitumor reagent innanti-methionine chemotherapy. Specifically, methioninase is used to slow or stop cellndivision which can be enhanced with competitive inhibitors of methionine. In addition,nmethioninase can be used in combination with anti-mitotic agents to increase thentherapeutic effectiveness of the anti-mitotic by inducing cell cycle synchronization. |