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filingDate 2000-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2006-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba6488ec9ac091693334ba0b0cc36531
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publicationDate 2006-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1286658-B1
titleOfInvention Gamma-ifn liquid-droplet aerosol and method
abstract A liquid-droplet aerosol composition for delivery to a patient's respiratory tract is disclosed. The aerosol is formed by placing an aqueous gamma-IFN solution having stabilizing and dispersing components against a plate having defined-size openings, and forcing the solution through the openings under conditions effective to form aqueous droplets having a volume mean diameter in one or more of a number of selected sizes in the 1-10 micron size range. The aerosol has the desired-size droplets and a gamma-IFN biological activity and molecular size distribution substantially the same as that of the aqueous gamma-IFN solution. Also disclosed is a method of administering to a selected region of a patient's respiratory tract, an amount of human gamma-IFN having a known, selected gamma-interferon biological activity and molecular size distribution.
priorityDate 1999-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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