| abstract |
Methods for identifying a compound that binds to a target are described. Inngeneral, the methods involve forming a first library comprising a multiplicity of peptides,nidentifying one or more peptides that bind to the target and determining a peptide motifntherefrom, forming a second library comprising a multiplicity of compounds designednbased on the peptide motif, selecting from the second library at least one compound thatnbinds to the target, and determining the structure or structures of the at least one compoundnthat binds to the target. Libraries of compounds based on a peptide motif and compoundsnidentified by the methods of the invention are also disclosed. |