| abstract |
The invention provides isolated nucleic acids molecules, designated SCDR nucleic acid molecules, which encode novel SCDR-related short-chain dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SCDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SCDR gene has been introduced or disrupted. The invention still further provides isolated SCDR proteins, fusion proteins, antigenic peptides and anti-SCDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided. |