http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1278832-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42f352cc5bd193c17ffff15bf60e16f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13e53d9d416350331cac40678c0c19ab |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate | 2001-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dba95066e69f79e99d7e09a9213fc72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_638a971a55af2febc7f5036d328dac8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79a45e682a467cac2ef81757ab197715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a852b07d3665f66f3f7b36e3de3831c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6537be2652717b76ac54406827dfbbd4 |
| publicationDate | 2003-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1278832-A1 |
| titleOfInvention | Methods and compositions for effecting homologous recombination |
| abstract | This invention concerns a method for effecting homologous recombination between a native nucleic acid segment in a cell and a donor nucleic acid segment introduced into the cell, which comprises: a) introducing into a cell a nucleic acid delivery system comprising: (i) an oligonucleotide third strand which comprises a base sequence capable of forming a triple helix at a binding region on one or both strands of a native nucleic acid segment, (ii) a donor nucleic acid, comprising a nucleic acid sequence sufficiently homologous to the native nucleic acid segment such that the donor sequence is capable of undergoing homologous recombination with the native sequence at the target region, (iii) an adapter segment comprising an oligonucleotide sequence able to bind at least a portion of said donor nucleic acid through Watson-Crick base pairing, the adapter segment being linked to said oligonucleotide third strand, b) allowing the oligonucleotide to bind to the native nucleic acid segment to form a triple helix nucleic acid, thereby inducing homologous recombination at the native nucleic acid segment target region; and c) allowing homologous recombination to occur between the native and donor nucleic acid segments. The method may namely be implemented for effecting gene alteration or mutation repair at a specific sequence site on a native DNA. |
| priorityDate | 2000-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.