| abstract |
The invention relates to new C 14 -C 15 bridged Estra-1,3,5 (10) -triene-amidosulfamates which carry an R-SO 2 -O group at the 3-position, where R is an R 1 R 2 N group or R 1 is NH group, in which R 1 and R 2 independently of one another represent an alkyl radical with 1-5 C atoms or together with the N atom a polymethyleneimino radical with 4 to 6 C atoms or a morpholino radical.n n n The compounds of the invention are hormonalnContraception and in menopausal hormone replacement therapy (HRT)nas well as for the treatment of gynecologicalnand andrological clinical pictures.nThe compounds according to the invention therefore have only onenlow hepatic estrogenicity.n n n Furthermore, methods for producing the inventionnConnections described, as well as for the preparationnpharmaceutical compositions. |