| abstract |
The invention relates to the use of IL-15 inhibiting or eliminating compounds thatninterfere with the binding of IL-15 to its receptor for the manufacture of anpharmaceutical composition for suppression of formation of CD4 + memory cells of thenimmune system. Such inhibiting or eliminating compounds are for example anti-IL-15nantibodies, anti-IL-15Rα antibodies, fragments of these antibodies, e.g. the Fab ornF(ab') 2 fragment, soluble IL-15Rα, fusion proteins consisting of soluble IL-15Rα, andnFc fragment, compounds, e.g. peptides, binding and/or inhibiting functional IL-15nreceptor, IL-15 antisense oligonucleotides. |