| abstract |
A process for preparing an emulsion composition comprising rapamycin or a derivative thereof asnactive agent, which process comprises the step of admixing to a placebo fat emulsion anconcentrate comprisingn a) the active agent, b) a stabiliser selected from a phospholipid, a glycolipid, a sphingolipid, a diacylphosphatidylnglycerol, an egg-phosphatidylglycerol, a soy-phosphatidylglycerol, or a salt thereof; or ansaturated, mono- or di-unsaturated (C 12-24 ) fatty acid, or a salt thereof, and c) an organic solvent, n wherein the weight ratio of acitve agent to stabiliser is between 400:1 and 0.5:1. n The invention also provides ready-to-use emulsions, e.g. for intravenous administration, preparednusing the above process. |